Children |
| 1. Empress Eleonora de Medici, b. 28 Feb 1567, Florence, Florence, Tuscany, Italy , d. 9 Sep 1611, Cavriana, Mantova, Lombardia, Italy (Age 44 years) |
| 2. Romola Princess of Tuscany de Medici, b. 20 Nov 1568, Of, Firenze, Firenze, Italy , d. 2 Dec 1658, Firenze, Firenze, Toscana, Italy (Age 90 years) |
| 3. Princess of Tuscany, Anna de Medici, b. 31 Dec 1569, Florence, Florence, Tuscany, Italy , d. 19 Feb 1584, Florence, Provincia di Firenze, Toscana, Italy (Age 14 years) |
| 4. Isabella de Medici, b. 30 Sep 1571, Firenze, Firenze, Tuscany, Italy , d. 8 Aug 1572, Firenze, Firenze, Tuscany, Italy (Age 0 years) |
| 5. Lucrezia di Francesco de Medici, b. 7 Nov 1572, Firenze, Firenze, Tuscany, Italy , d. 14 Aug 1574, Firenze, Firenze, Tuscany, Italy (Age 1 years) |
+ | 6. Reine Marie de Médici, 2nd wife, b. 26 Apr 1573, Florence, Firenze, Toscana, Italy , d. 3 Jul 1642, Cologne, Koln, Nordrhein-Westfalen, Germany (Age 69 years) |
| 7. Antonio de Medici,, Knight of Malta, b. 29 Aug 1576, Firenze, Firenze, Tuscany, Italy , d. 2 May 1621, Firenze, Firenze, Tuscany, Italy (Age 44 years) |
| 8. Felipe De Medici, b. 20 May 1577, Firenze, Firenze, Tuscany, Italy , d. 12 Mar 1644, Soham, Cambridge, England (Age 66 years) |
| 9. de Medici, b. 10 Apr 1578, Firenze, Firenze, Tuscany, Italy , d. 10 Apr 1578, Firenze, Firenze, Tuscany, Italy (Age 0 years) |
|